Publications
SUNY Upstate
Monovalent SARS-COV-2 mRNA Vaccine Using Optimal UTRs and LNPs Is Highly Immunogenic and Broadly Protective Against Omicron Variants
Z Ye, S Bonam, L McKay, J Plante, J Walker, Y Zhao, C Huang, J Chen, C Xu, Y Li, L Liu, J Harmon, S Gao, D Song, Z Zhang, K Plante, A Griffiths, J Chen, H Hu*, Q Xu*
Proceedings of the National Academy of Sciences 120 (52), e2311752120 (2023) [LINK]
The mRNA Vaccine Revolution: COVID-19 Has Launched the Future of Vaccinology
Z Ye, J Harmon, W Ni, Y Li, D Wich, Q Xu*
ACS Nano 17 (16), 15231–15253 (2023) [LINK]
Adaptive c-Met-PLXDC2 Signaling Axis Mediates Cancer Stem Cell Plasticity to Confer Radioresistance-associated Aggressiveness in Head and Neck Cancer
L Lang, F Chen, Y Li, C Shay, F Yang, H Dan, Z Chen, N Saba, Y Teng*
Cancer Research Communications 3 (4), 659-671 (2023) [LINK]
Clinical Progress in Genome-Editing Technology and In Vivo Delivery Techniques
J Khirallah, M Eimbinder, Y Li*, Q Xu*
Trends in Genetics, 39, 208-216 (2023) [LINK]
Invited Review Article
Patterns of Toxicity Burden for FDA-approved Immune Checkpoint Inhibitors in the United States
F Yang, C Shay, M Abousaud, C Tang, Y Li, Z Qin, N Saba, Y Teng*
Journal of Experimental & Clinical Cancer Research, 42, 4 (2023) [LINK]
In Vivo Delivery of CRISPR-Cas9 Genome Editing Components for Therapeutic Applications
K Huang, D Zapata, Y Tang, Y Teng*, Y Li*
Biomaterials, 291, 121876 (2022) [LINK]
Tailoring Combinatorial Lipid Nanoparticles for Intracellular Delivery of Nucleic Acids, Proteins, and Drugs
Y Li, Z Ye, G Yang, Q Xu*
Acta Pharmaceutica Sinica B, 12 (6), 2624-2639 (2022) [LINK]
Invited Review Article for the A New Era of Nanobiomaterial-based Drug Delivery Special Issue
Tufts
Investigating the Cytosolic Delivery of Proteins by Lipid Nanoparticles Using the Chloroalkane Penetration Assay
J Wang, S Zhang, Y Li, Q Xu, J Kritzer*
Biochemistry (2024) [LINK]
Published as part of Biochemistry virtual special issue “Drug Delivery”.
CRISPR/Cas9-Mediated Genome and Epigenome Editing in Mammalian Cells
H Bloomer, J Khirallah, Y Li*, Q Xu*
Advanced Drug Delivery Reviews, 181, 114087 (2022) [LINK]
Invited Review Article for the RNA-Binding Proteins as Molecular Targets for Cancer Therapy Special Issue
Lipid Nanoparticle-mediated Lymph Node-Targeting Delivery of mRNA Cancer Vaccine Elicits Robust CD8+ T Cell Response
J Chen#, Z Ye#, C Huang, M Qiu, D Song, Y Li, Q Xu*
Proceedings of the National Academy of Sciences, 119 (34), e2207841119 [LINK]
In Vitro Engineering Chimeric Antigen Receptor Macrophages and T Cells by Lipid Nanoparticle-Mediated mRNA Delivery
Z Ye, J Chen, X Zhao, Y Li, J Harmon, C Huang, J Chen, Q Xu*
ACS Biomaterials Science & Engineering, 8 (2), 722-733 (2022) [LINK]
Developing Biodegradable Lipid Nanoparticles for Intracellular mRNA Delivery and Genome Editing
M Qiu#, Y Li#, H Bloomer, Q Xu*
Accounts of Chemical Research, 54 (21), 4001-4011 (2021) [LINK]
Invited Review Article for the mRNA Therapeutics Special Issue
Study the Lipidoid Nanoparticle Mediated Genome Editing Protein Delivery Using 3D Intestinal Tissue Model
T Yang, H Han, Y Chen, L Yang, R Parker, Y Li, D Kaplan*, Q Xu*
Bioactive Materials, 6 (11), 3671-3677 (2021) [LINK]
Editor-in-Chief Invited Research Article
Scaffold-Mediated CRISPR/Cas9 Delivery System for Acute Myeloid Leukemia Therapy
T Ho, H Kim, Y Chen, Y Li, M LaMere, C Chen, H Wang, J Gong, C Palumbo, J Ashton, H Kim, Q Xu, M Becker*, K Leong*
Sciences Advances, 7 (21), eabg3217 (2021) [LINK]
In Situ Cancer Vaccination Using Lipidoid Nanoparticles
J Chen, M Qiu, Z Ye, T Nyalile, Y Li, Z Glass, X Zhao, L Yang, J Chen, Q Xu*
Science Advances, 7, eabf1244 (2021) [LINK]
Lipid Nanoparticle-Mediated Co-delivery of Cas9 mRNA and Single-guide RNA Achieves Liver-Specific In Vivo Genome Editing of Angptl3
M Qiu#, Z Glass#, J Chen, X Zhao, X Rui, Z Ye, Y Li, F Zhang, Q Xu*
Proceedings of the National Academy of Sciences, 118, e2020401118 (2021) [LINK]
Intracellular Antibody Delivery Mediated by Lipids, Polymers, and Inorganic Nanomaterials for Therapeutic Applications
Y Li, P Li, R Li, Q Xu*
Advanced Therapeutics, 3 (12), 2000178 (2020) [LINK]
Imidazole-Based Synthetic Lipidoids for In Vivo mRNA Delivery into Primary T Lymphocytes
X Zhao#, J Chen#, M Qiu, Y Li, Z Glass, Q Xu*
Angewandte Chemie International Edition, 59 (45), 20083-20089 (2020) [LINK]
Combinatorial Library of Cyclic Benzylidene Acetal-Containing pH-Responsive Lipidoid Nanoparticles for Intracellular mRNA Delivery
Y Li, R Li, A Chakraborty, R Ogurlu, X Zhao, J Chen, Q Xu*
Bioconjugate Chemistry, 31 (7), 1835-1843 (2020) [LINK]
Protein and mRNA Delivery Enabled by Cholesteryl-Based Biodegradable Lipidoid Nanoparticles
Y Li, R Jarvis, K Zhu, Z Glass, R Ogurlu, P Gao, P Li, J Chen, Y Yu, Y Yang, Q Xu*
Angewandte Chemie International Edition, 59 (35), 14957-14964 (2020) [LINK]
In Vitro and In Vivo Study of an Amphotericin B Formulation with Quaternized Bioreducible Lipidoids
F Liu#, L Yang#, Y Li#, A Junier, F Ma, J Chen, H Han, Z Glass, X Zhao, C Kumamoto, H Song*, Q Xu*
ACS Biomaterials Science & Engineering, 6 (2), 1064-1073 (2020) [LINK]
Ex vivo Cell-Based CRISPR/Cas9 Genome Editing for Therapeutic Applications
Y Li, Z Glass, Q Xu*
Biomaterials, 234, 119711 (2020) [LINK]
Editor-in-Chief Invited Review Article
Intracellular Delivery of Genome Editing Proteins Enabled by Nitrilotriacetic Acid-Containing Lipidoid Nanoparticles
Y Li, A Li, Q Xu*
Advanced Healthcare Materials, 8 (6), 180996 (2019) [LINK]
Invited Research Article for the Molecular Engineering, from Molecule to Medicine Special Issue
Featured on Front Cover [LINK]
Combinatorial Library of Light-Cleavable Lipidoid Nanoparticles for Intracellular Drug Delivery
Y Li, A Chakraborty, J Chen, Q Xu*
ACS Biomaterials Science & Engineering, 5, 2391-2398 (2019) [LINK]
Intracellular Delivery and Biodistribution Study of CRISPR/Cas9 Ribonucleoprotein Loaded Bioreducible Lipidoid Nanoparticles
Y Li, J Bolinger, Y Yu, Z Glass, N Shi, L Yang, M Wang, Q Xu*
Biomaterials Science, 7, 597-606 (2019) [LINK]
Invited Research Article for the Biomaterials Science Emerging Investigators Special Issue
A Novel Non-Surgical Method to Reduce Fertility Using The Rat as A Model
K Meadows*, Y Li, Q Xu, S Ayres
Clinical Theriogenology, 11, 31-41 (2019) [LINK]
3D Printing of Silk Protein Structures by Aqueous Solvent-Directed Molecular Assembly
X Mu, Y Wang, C Guo, Y Li, S Ling, W Huang, P Cebe, H Hsu, F Ferrari, X Jiang, Q Xu, A Balduini, F Omenetto, D Kaplan*
Macromolecular Bioscience, e1900191 (2019) [LINK]
Preprint on ChemRxiv, DOI: 10.26434/chemrxiv.8206469 [LINK]
A Novel Xenograft Mouse Model for Testing Approaches Targeting Human Kappa Light-Chain Diseases
X Ma, P Zhou, A Kugelmass, D Toskic, M Warner, L Lee, T Fogaren, A Godara, M Wang, Y Li, L Yang, Q Xu, R Comenzo*
Gene Therapy, 26, 187-197 (2019) [LINK]
Combinatorial Library of Chalcogen-Containing Lipidoids for Intracellular Delivery of Genome-Editing Proteins
Y Li#, T Yang#, Y Yu, N Shi, L Yang, Z Glass, J Bolinger, I Finkel, W Li, Q Xu*
Biomaterials, 178, 652-662 (2018) [LINK]
Invited Research Article for the Chemistry of Biomaterials Special Issue
Rescued from the Fate of Neurological Disorder
Y Li, Z Glass, Q Xu*
Nature Biomedical Engineering, 2, 469-470 (2018) [LINK]
Invited News & Views
Treatment of Autosomal Dominant Hearing Loss by In Vivo Delivery of Genome Editing Agents
X Gao, Y Tao, V Lamas, M Huang, W Yeh, B Pan, Y Hu, J Hu, D Thompson, Y Shu, Y Li, H Wang, S Yang, Q Xu, D Polley, M Liberman, W Kong, J Holt, Z Chen*, D Liu*
Nature, 553, 217-221 (2018) [LINK]
Engineering the Delivery Systems for CRISPR-Based Genome Editing
Z Glass, M Lee, Y Li, Q Xu*
Trends in Biotechnology, 36, 173-185 (2018) [LINK]
Effective Lipidoid Nanoparticle Delivery In Vivo of siRNA Targeting Kappa Light Chain Production in a Murine Xenograft Model
X Ma, P Zhou, A Kugelmass, D Toskic, M Warner, L Lee, T Fogaren, M Wang, Y Li, L Yang, Q Xu, R Comenzo*
Blood, 132, 3208 (2018) [LINK]
Hyaluronic Acid Modification of RNase A and Its Intracellular Delivery Using Lipid-Like Nanoparticles
X Wang#, Y Li#, Q Li, C Neufeld, D Pouli, S Sun, L Yang, P Deng, M Wang, I Georgakoudi, S Tang, Q Xu*
Journal of Controlled Release, 263, 39-45 (2017) [LINK]
Invited Research Article for the Nano Drug Delivery Systems Special Issue
Nanoparticles for CRISPR-Cas9 Delivery
Z Glass, Y Li, Q Xu*
Nature Biomedical Engineering, 1, 854-855 (2017) [LINK]
Invited News & Views
Book Chapter
Non-Viral Genome Editing in Cancer Immunotherapy
Y Li, Q Xu
Systemic Drug Delivery Strategies (Elsevier Press), 2, 257-272 (2022) [LINK]
Chemical Modification of Proteins and Their Intracellular Delivery Using Lipidoid Nanoparticles
Y Li, Z Glass, Q Xu
Biomedical Engineering Technologies (Humana Press), 2394, 555-573 (2020) [LINK]
USTC
Cytosolic NQO1 Enzyme-Activated Near-Infrared Fluorescence Imaging and Photodynamic Therapy with Polymeric Vesicles
C Yao, Y Li, Z Wang, C Song, X Hu, S Liu*
ACS Nano, 14, 1919-1935 (2020) [LINK]
Enzyme-Triggered Transition from Polymeric Vesicles to Core Cross-Linked Micelles for Selective Release of Antimicrobial Agents
Y Li, S Liu*
Acta Polymerica Sinica, 7, 1178-1190 (2017) [LINK]
Invited Research Article for the 60th Journal Anniversary Special Issue
Enzyme-Responsive Polymeric Vesicles for Bacterial Strain-Selective Delivery of Antimicrobial Agents
Y Li, G Liu, X Wang, J Hu, S Liu*
Angewandte Chemie International Edition, 55, 1760-1764 (2016) [LINK]
Amphiphilic Star Copolymer-Based Bimodal Fluorogenic/Magnetic Resonance Probes for Concomitant Bacteria Detection and Inhibition
Y Li, H Yu, Y Qian, J Hu, S Liu*
Advanced Materials, 26, 6734-6741 (2014) [LINK]
Polyion Complex Micellar Nanoparticles for Integrated Fluorometric Detection and Bacteria Inhibition in Aqueous Media
Y Li, X Hu, S Tian, Y Li, G Zhang, G Zhang*, S Liu*
Biomaterials, 35, 1618-1626 (2014) [LINK]
Light-Triggered Concomitant Enhancement of Magnetic Resonance Imaging Contrast Performance and Drug Release Rate of Functionalized Amphiphilic Diblock Copolymer Micelles
Y Li, Y Qian, T Liu, G Zhang, S Liu*
Biomacromolecules, 13, 3877-3886 (2012) [LINK]